Investigating how venous issues affect brain health after a type of stroke.
Official title: The role of venous impairment in subarachnoid hemorrhage pathophysiology
Funded at Loma Linda University · NIH-11012883 · Data updated 2026-11-12
This study is looking at how problems with blood flow in the veins can affect people who have had a serious type of stroke called aneurysmal subarachnoid hemorrhage, and it hopes to find new ways to help them recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $201,191 |
| NIH project number | 5R21NS135655-02 |
| Project ID | NIH-11012883 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an aneurysmal subarachnoid hemorrhage or have related venous circulation issues.
✕Less likely to help
Patients with other types of strokes or those without any venous circulation problems may not benefit from this research.
What this research studies
This research focuses on understanding the impact of venous impairment on patients who experience aneurysmal subarachnoid hemorrhage (SAH), a serious type of stroke. By using a new mouse model that simulates SAH with blocked jugular veins, the study aims to explore how these venous issues can lead to increased pressure in the brain and worsen patient outcomes. The researchers will analyze how variations in cerebral venous drainage and obstructions can affect cerebrospinal fluid flow and overall brain health. This could provide insights into new treatment strategies for improving recovery in SAH patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients suffering from aneurysmal subarachnoid hemorrhage.
How similar studies have gone: While the focus on venous impairment in SAH is relatively novel, previous research has shown that understanding vascular issues can significantly impact treatment outcomes in stroke patients.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Zhang, John H — Loma Linda University
- Study coordinator: Zhang, John H
Related research
Other NIH-funded projects on the same topics.
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Cognitive screening after an aneurysmal brain bleed
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
-
Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
-
3D brain blood vessel model to study subarachnoid hemorrhage and test therapies
A researcher will develop a 3D printed, biomimetic brain model to study subarachnoid hemorrhage and screen potential nanoparticle-based treatments.
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Biomarkers to Fine-Tune Intrathecal Nicardipine for Brain Bleeding-Related Stroke
Researchers are testing biomarkers to personalize intrathecal nicardipine treatment for patients after subarachnoid hemorrhage to prevent brain damage.
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Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
-
Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.