Investigating how venous issues affect brain health after a type of stroke.
The role of venous impairment in subarachnoid hemorrhage pathophysiology
This study is looking at how problems with blood flow in the veins can affect people who have had a serious type of stroke called aneurysmal subarachnoid hemorrhage, and it hopes to find new ways to help them recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project ID | NIH-11012883 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of venous impairment on patients who experience aneurysmal subarachnoid hemorrhage (SAH), a serious type of stroke. By using a new mouse model that simulates SAH with blocked jugular veins, the study aims to explore how these venous issues can lead to increased pressure in the brain and worsen patient outcomes. The researchers will analyze how variations in cerebral venous drainage and obstructions can affect cerebrospinal fluid flow and overall brain health. This could provide insights into new treatment strategies for improving recovery in SAH patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an aneurysmal subarachnoid hemorrhage or have related venous circulation issues.
Not a fit: Patients with other types of strokes or those without any venous circulation problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients suffering from aneurysmal subarachnoid hemorrhage.
How similar studies have performed: While the focus on venous impairment in SAH is relatively novel, previous research has shown that understanding vascular issues can significantly impact treatment outcomes in stroke patients.
Where this research is happening
Loma Linda, UNITED STATES
- Loma Linda University — Loma Linda, United States (Active)
Researchers
- Principal investigator: Zhang, John H — Loma Linda University
- Study coordinator: Zhang, John H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.