Investigating how venetoclax works with other drugs in treating acute myeloid leukemia
Mechanisms of venetoclax combination activity in acute myeloid leukemia
This study is looking at how well the drug venetoclax works for people with acute myeloid leukemia (AML), especially when it's used with other treatments, to find the best combinations that could help patients feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11099796 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind the effectiveness of venetoclax, a drug used to treat acute myeloid leukemia (AML), especially when combined with other treatments like hypomethylating agents. The team has been studying patient samples to identify better drug combinations that could improve treatment outcomes. They aim to translate their findings into clinical trials, testing the most promising combinations to enhance patient responses and survival rates. By analyzing the biology of these drug interactions, the researchers hope to uncover biomarkers that predict which patients will benefit the most.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who may benefit from new treatment combinations involving venetoclax.
Not a fit: Patients with other types of leukemia or those who have already exhausted all treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment combinations for patients with acute myeloid leukemia, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results with venetoclax in combination therapies, indicating a potential for success in this novel approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Tyner, Jeffrey Wallace — Oregon Health & Science University
- Study coordinator: Tyner, Jeffrey Wallace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.