Investigating how vein cells affect graft failure in heart surgery
The effect of adventitial vein cells on vein graft neointimal hyperplasia
This study is looking at why veins used in heart surgeries sometimes don't work well and is testing a new drug to see if it can help keep those veins healthy, which could lead to better options for people having bypass surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10767125 on NIH RePORTER |
What this research studies
This research focuses on understanding why saphenous vein grafts, commonly used in heart surgeries, often fail due to a condition called neointimal hyperplasia. By using a unique model that involves implanting human veins into specially bred rats, the researchers aim to explore the role of adventitial cells in preventing this failure. They will also test a new drug, SB-030, to see if it can help reduce the growth of cells that contribute to graft failure. The findings could lead to improved treatments for patients undergoing bypass surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing coronary artery bypass grafting who may be at risk for graft failure.
Not a fit: Patients who have not undergone vein graft procedures or those with conditions unrelated to coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better outcomes for patients receiving vein grafts in heart surgeries, reducing the risk of graft failure.
How similar studies have performed: Previous research has shown promise in using similar approaches to improve graft outcomes, suggesting potential for success in this study.
Where this research is happening
Seattle, United States
- VA Puget Sound Healthcare System — Seattle, United States (Active)
Researchers
- Principal investigator: Tang, Gale Lynn — VA Puget Sound Healthcare System
- Study coordinator: Tang, Gale Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.