Investigating how VEGF and Neuropilin-2 contribute to treatment resistance in aggressive breast cancer.

Who could benefit from this research

What this research studies

This research focuses on Triple-Negative Breast Cancer (TNBC), a particularly aggressive form of breast cancer that often does not respond well to standard treatments. The study aims to understand how the signaling pathways involving Vascular Endothelial Growth Factor (VEGF) and Neuropilin-2 (NRP2) contribute to the cancer's resistance to radiation therapy. By examining how these pathways affect the accumulation of reactive oxygen species (ROS) in cancer cells, researchers hope to identify new therapeutic targets. The use of advanced techniques like single-cell RNA sequencing will help pinpoint specific subpopulations of TNBC that are resistant to treatment, potentially leading to more effective strategies for overcoming this resistance.

Why it matters

Where this research is happening

• Univ of Massachusetts Med Sch Worcester
  Worcester, United States Active

Researchers

• Principal investigator: Kumar, Ayush — Univ of Massachusetts Med Sch Worcester
• Study coordinator: Kumar, Ayush

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

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  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

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  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.