Investigating how vascular leak contributes to atrial fibrillation
Targeting Vascular Leak and Intercalated Disk Nanodomains to Prevent Atrial Fibrillation
This study is looking at how inflammation in the body might cause fluid leaks that can lead to atrial fibrillation, a common heart condition, and aims to find new ways to help manage it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10884356 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between inflammation, vascular leak, and atrial fibrillation (AF), a condition affecting many individuals. The team will explore how elevated levels of inflammatory cytokines lead to vascular leak, which may cause cardiac edema and disrupt the normal functioning of heart cells. Using advanced imaging techniques and experimental models, the researchers aim to uncover the mechanisms by which these factors contribute to the development of AF. This could lead to new therapeutic strategies for managing this common heart condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with atrial fibrillation, particularly those experiencing symptoms related to inflammation or vascular issues.
Not a fit: Patients without a diagnosis of atrial fibrillation or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that prevent or reduce the occurrence of atrial fibrillation.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in arrhythmias, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Veeraraghavan, Rengasayee — Ohio State University
- Study coordinator: Veeraraghavan, Rengasayee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.