Investigating how vascular disease affects cognitive decline in CADASIL compared to normal aging
Non-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal Aging
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11036339
This study is looking at how blood vessel problems affect thinking and memory in people with CADASIL, a rare genetic condition, by using MRI scans to see how their brains are doing over time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11036339 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of vascular disease in cognitive impairment and dementia, specifically in individuals with CADASIL, a rare genetic disorder. By using non-invasive MRI techniques, the study aims to explore how small vessel disease impacts brain health and cognitive function over time. Participants will undergo MRI scans to assess brain structure and function, helping to identify early signs of cognitive decline related to vascular issues. The findings could provide valuable insights into the relationship between vascular health and dementia, potentially influencing future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with the CADASIL genetic mutation, including both symptomatic and asymptomatic carriers.
Not a fit: Patients without the CADASIL mutation or those with other unrelated forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive decline in patients with vascular contributions to dementia.
How similar studies have performed: Previous research has shown promising results in using MRI to study vascular contributions to cognitive impairment, indicating that this approach has potential for success.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EISENMENGER, LAURA BURNS — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: EISENMENGER, LAURA BURNS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.