Investigating how variant chromatin structures affect gene expression in cells
Official title: Variant Chromatin Structures-Targeting and Functions
Funded at State University New York Stony Brook · NIH-11011624 · Data updated 2026-11-12
This study is looking at a special protein called H2A.Z that helps control how genes are turned on and off, which is important for development, and the findings could lead to new treatments for patients by improving our understanding of gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $568,113 |
| NIH project number | 1R35GM156364-01 |
| Project ID | NIH-11011624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders linked to chromatin structure and gene regulation.
✕Less likely to help
Patients with conditions unrelated to chromatin structure or gene expression may not receive any benefit from this research.
What this research studies
This research focuses on understanding variant chromatin structures in eukaryotic cells, particularly how these structures are targeted to specific genomic sites and their functions. The study examines the histone variant H2A.Z, which plays a crucial role in gene transcription and early animal development. By employing biochemical and genomic techniques, the research aims to uncover the mechanisms by which H2A.Z influences the transcription process, potentially impacting how genes are expressed during development. Patients may benefit from insights gained into gene regulation that could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may improve treatments for various genetic disorders.
How similar studies have gone: Previous research has shown promising results in understanding chromatin dynamics and their impact on gene expression, suggesting that this approach has potential for success.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Luk, Edward E — State University New York Stony Brook
- Study coordinator: Luk, Edward E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.