Investigating how vaccines can induce protective immunity against HIV
Official title: Core B: Non-human Primate Core
Funded at Univ of North Carolina Chapel Hill · NIH-11059122 · Data updated 2026-11-12
This study is looking at how to create a strong vaccine for HIV/AIDS by learning how certain antibodies are made in young monkeys, which could help us understand how to protect people from the virus for a long time.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $252,829 |
| NIH project number | 5P01AI178377-03 |
| Project ID | NIH-11059122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include infants and adults at risk for HIV infection.
✕Less likely to help
Patients who are already living with HIV/AIDS may not directly benefit from this research.
What this research studies
This research focuses on developing an effective vaccine for HIV/AIDS by studying how broadly neutralizing antibodies (bnAbs) can be induced. It utilizes non-human primates, specifically infant rhesus macaques, to explore the biological factors that influence B cell differentiation and the development of these antibodies. The research employs systems biology approaches to analyze immune responses and the role of the intestinal microbiome in vaccine effectiveness. By understanding these mechanisms, the goal is to create a vaccine that provides long-term protection against HIV.
Why it matters
Potential benefit: If successful, this research could lead to the development of a highly effective HIV vaccine, significantly reducing the incidence of HIV/AIDS.
How similar studies have gone: Previous research has shown promise in developing bnAbs in non-human primates, indicating potential success for this approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: De Paris, Kristina — Univ of North Carolina Chapel Hill
- Study coordinator: De Paris, Kristina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.