Investigating how uterine signaling affects lung disease in women
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)
This study is looking into lymphangioleiomyomatosis (LAM), a rare lung disease that mainly affects women, to better understand how certain signals from the uterus might play a role in the disease and to find new ways to improve treatment for those living with LAM.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10633293 on NIH RePORTER |
What this research studies
This research focuses on lymphangioleiomyomatosis (LAM), a rare lung disease primarily affecting women of reproductive age. It aims to understand the underlying mechanisms of LAM, particularly how uterine-specific signaling pathways may contribute to the disease's development and progression. By analyzing genetic factors and cellular behaviors in LAM patients, the research seeks to uncover potential new therapeutic targets and improve treatment outcomes. The study utilizes advanced techniques like single-cell RNA sequencing to identify unique cell populations involved in LAM.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who have been diagnosed with lymphangioleiomyomatosis.
Not a fit: Patients with LAM who are not of reproductive age or those with other unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms driving LAM, potentially improving lung function and quality of life for affected patients.
How similar studies have performed: While research on LAM is limited, preliminary findings suggest that understanding uterine signaling in this context could lead to significant advancements, indicating a novel approach to treatment.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Xu, Yan — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Xu, Yan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.