Investigating how Urotensin II affects kidney function in growth-restricted infants.
Official title: Urotensin II and renal insufficiency in growth-restricted infants.
Funded at University of Missouri-Columbia · NIH-10908605 · Data updated 2026-11-12
This study is looking at how a substance called Urotensin II might affect the kidneys of babies who didn't grow as much as expected before birth, with the hope of finding ways to help these little ones stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 3, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $592,319 |
| NIH project number | 5R01DK127625-06 |
| Project ID | NIH-10908605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who are diagnosed with intrauterine growth restriction.
✕Less likely to help
Patients who are not newborns or do not have a history of intrauterine growth restriction may not benefit from this research.
What this research studies
This research focuses on understanding the role of Urotensin II (UII), a peptide that influences kidney function, in infants who have experienced intrauterine growth restriction (IUGR). The study aims to explore how increased levels of UII may contribute to kidney injury in these newborns. By using a preclinical model of growth-restricted pigs, researchers will examine the mechanisms through which UII affects renal function and overall health. The goal is to identify potential interventions that could improve outcomes for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for kidney issues in growth-restricted infants, potentially reducing long-term health complications.
How similar studies have gone: Previous research has shown that understanding the role of vasoactive peptides like Urotensin II can lead to significant insights into kidney function, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Adebiyi, Adebowale — University of Missouri-Columbia
- Study coordinator: Adebiyi, Adebowale
Related research
Other NIH-funded projects on the same topics.
-
Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
-
Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
-
Understanding Kidney Disease and Heart Health
This long-running project gathers information from people with reduced kidney function to better understand how kidney disease progresses and affects heart health.
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Johns Hopkins continuation of the Chronic Kidney Disease (CRIC) cohort
This project continues long-term follow-up of adults with chronic kidney disease to collect health information, tests, and samples that help understand kidney and heart complications.
-
Tracking kidney disease and heart health in adults
This project follows adults with reduced kidney function to learn how kidney disease progresses and how it affects heart health and other health problems.
-
Tulane Chronic Kidney Disease (CKD) Cohort
Following thousands of adults with reduced kidney function to learn what factors influence kidney decline and heart disease risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.