Investigating how uremic toxins affect bone health in chronic kidney disease
Uremic toxins and osteocyte dysfunction in CKD
This study is looking at how a harmful substance that builds up when your kidneys aren't working well affects bone health, especially the risk of hip fractures, in people with chronic kidney disease, and it’s testing whether changing your diet can help improve bone strength.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10993611 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of uremic toxins, specifically indoxyl sulfate, on bone health in individuals with chronic kidney disease (CKD). It explores how these toxins accumulate due to reduced kidney function and their role in bone fragility, particularly in relation to hip fractures. The study employs a combination of dietary interventions, such as the administration of inulin, to modify gut microbiota and reduce toxin levels, alongside laboratory models to assess changes in bone cell behavior and function. By examining these relationships, the research aims to identify new therapeutic strategies to improve bone health in CKD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with chronic kidney disease.
Not a fit: Patients with normal kidney function or those who do not have chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance bone health and reduce fracture risk in patients with chronic kidney disease.
How similar studies have performed: Previous studies have shown promising results in modifying gut microbiota to reduce uremic toxins and improve bone health, indicating that this approach has potential for success.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Moe, Sharon M — Indiana University Indianapolis
- Study coordinator: Moe, Sharon M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.