Investigating how upward mobility affects Alzheimer's risk differently in young men and women
Official title: Testing sex as a moderator of health impacts of upward mobility on indicators for AD risk in young adulthood
Funded at University of California Los Angeles · NIH-10984410 · Data updated 2026-11-12
This study is looking at how growing up in a tough financial situation might affect the chances of developing Alzheimer's disease later on, especially for young women, by checking how stress impacts health and brain function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $769,710 |
| NIH project number | 1R01AG089426-01 |
| Project ID | NIH-10984410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young adults aged 23 who have experienced upward mobility and may have risk factors for Alzheimer's Disease.
✕Less likely to help
Patients who have not experienced upward mobility or do not have relevant risk factors for Alzheimer's may not benefit from this research.
What this research studies
This research explores the relationship between upward mobility during adolescence and the risk of developing Alzheimer's Disease (AD) in young adulthood, focusing on how this impact may differ by sex. It examines how stress from striving to rise above poverty can affect physical health and cognitive outcomes, particularly in females who may experience greater stress-related health issues. The study will analyze data from young adults who have been part of a long-term follow-up study since 2003, assessing factors like inflammation and gut microbiome changes that could influence AD risk. By understanding these dynamics, the research aims to identify early indicators of AD risk linked to socioeconomic factors.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that help reduce Alzheimer's risk in young adults, particularly among those from disadvantaged backgrounds.
How similar studies have gone: Other research has shown promising results in understanding the links between socioeconomic factors and cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Callaghan, Bridget L — University of California Los Angeles
- Study coordinator: Callaghan, Bridget L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.