Investigating how Ubiquitin D variants affect kidney injury related to APOL1 in HIV patients
Official title: Effect of Ubiquitin D variants upon APOL1-mediated kidney injury
Funded at Albert Einstein College of Medicine · NIH-11009324 · Data updated 2026-11-12
This study is looking at how certain genetic changes in a protein called Ubiquitin D might affect kidney health in people with HIV, especially in African Americans, to help find new ways to prevent or treat kidney problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $252,000 |
| NIH project number | 1R21DK138863-01A1 |
| Project ID | NIH-11009324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals of African ancestry living with HIV, especially those with high-risk APOL1 genotypes.
✕Less likely to help
Patients who do not have HIV or those without APOL1 high-risk genotypes may not benefit from this research.
What this research studies
This research focuses on understanding the role of Ubiquitin D (UBD) variants in kidney injury caused by the APOL1 gene in individuals with HIV. It aims to explore how certain genetic factors, particularly in African American populations, contribute to the risk of chronic kidney disease (CKD) among those living with HIV. The study will analyze the interactions between UBD and APOL1, as well as other potential triggers that may lead to kidney damage. By examining these relationships, the research seeks to identify new pathways that could be targeted for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for kidney disease in individuals with HIV, particularly among those of African ancestry.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors contributing to kidney disease in similar populations, indicating that this approach has potential for success.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Ross, Michael J — Albert Einstein College of Medicine
- Study coordinator: Ross, Michael J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.