Investigating how tyrosine kinase inhibitors affect blood clotting and thrombosis
Tyrosine Kinases and Thrombosis
This study is looking at how a medication called ponatinib, used for treating chronic myelogenous leukemia, affects blood clotting in older mice, with the goal of understanding how it might cause problems like increased clot formation, so we can make this treatment safer for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11013368 on NIH RePORTER |
What this research studies
This research explores the effects of tyrosine kinase inhibitors (TKIs), specifically ponatinib, on blood coagulation and thrombosis in aged mice. By creating a murine model, the study examines how ponatinib influences arterial and venous thrombosis, leading to increased clot formation and vascular complications. The research aims to identify the underlying mechanisms, such as reactive oxygen species and inflammatory responses, that contribute to these adverse effects. The findings could help improve the safety of TKI treatments for patients with chronic myelogenous leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with chronic myelogenous leukemia who are being treated with tyrosine kinase inhibitors.
Not a fit: Patients who are not receiving tyrosine kinase inhibitors or those with conditions unrelated to blood coagulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment options for patients using tyrosine kinase inhibitors, reducing the risk of cardiovascular events.
How similar studies have performed: Previous research has indicated that tyrosine kinase inhibitors can have significant cardiovascular side effects, suggesting that this study builds on established findings rather than exploring a completely novel area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Schmaier, Alvin H — Case Western Reserve University
- Study coordinator: Schmaier, Alvin H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.