Investigating how Type IA topoisomerases work to combat antibiotic resistance
Structure, Mechanism and Interactions of Type IA Topoisomerases
This study is looking at important enzymes in bacteria that help keep their DNA in shape, with the goal of finding new ways to create antibiotics that can fight infections, especially those that are hard to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11011314 on NIH RePORTER |
What this research studies
This research focuses on understanding Type IA topoisomerases, which are essential enzymes in bacteria that help maintain DNA structure during critical cellular processes. By studying their mechanisms and interactions, the research aims to identify these enzymes as potential targets for new antibiotics. The approach involves biochemical and structural analyses to uncover how these enzymes function and how they can be manipulated to develop effective treatments against antibiotic-resistant infections. Patients may benefit from new antibiotic therapies developed from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens or those who are not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively combat antibiotic-resistant bacterial infections.
How similar studies have performed: Other research has shown promise in targeting bacterial topoisomerases for antibiotic development, indicating that this approach has potential for success.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Tse-Dinh, Yuk-Ching — Florida International University
- Study coordinator: Tse-Dinh, Yuk-Ching
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.