Investigating how type 1 diabetes affects brain development in children
Official title: Risk and Protective Factors for Neurocognitive Development in Type 1 Diabetes
Funded at University of California at Davis · NIH-10974722 · Data updated 2026-11-12
This study is looking at how type 1 diabetes affects the thinking and learning skills of children aged 6 to 11, especially those who have just been diagnosed, and it will follow them for over a year and a half to see how different factors, like blood sugar levels, impact their brain health compared to kids without diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $280,140 |
| NIH project number | 1U01DK140760-01 |
| Project ID | NIH-10974722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 6 to 11 who have recently been diagnosed with type 1 diabetes, particularly those who experienced diabetic ketoacidosis at onset.
✕Less likely to help
Children who do not have type 1 diabetes or are outside the age range of 6 to 11 years may not benefit from this research.
What this research studies
This research focuses on understanding the impact of type 1 diabetes (T1D) on neurocognitive development in children. It aims to identify risk and protective factors that influence cognitive function over time, particularly in children newly diagnosed with T1D. By comparing children with T1D to those without, the study will explore how factors like diabetic ketoacidosis and blood sugar levels affect brain health. The research will involve a longitudinal cohort of 800 children aged 6 to 11, who will be evaluated and followed for at least 1.5 years to track cognitive changes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing type 1 diabetes in children, potentially enhancing their cognitive function and overall quality of life.
How similar studies have gone: Previous research has indicated that understanding the cognitive impacts of chronic conditions like diabetes can lead to significant improvements in patient management, suggesting this approach has potential for success.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Ghetti, Simona — University of California at Davis
- Study coordinator: Ghetti, Simona
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.