Investigating how two proteins interact to regulate cell functions
EphA1 homotypic and EphA1-EphA2 heterotypic interactions in cell regulation
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11049238
This study is looking at how two important proteins, EphA1 and EphA2, work together and affect cell behavior, which could help us understand their roles in cancer and other diseases, and possibly lead to new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11049238 on ClinicalTrials.gov |
What this research studies
This research focuses on the interactions between two proteins, EphA1 and EphA2, which play crucial roles in regulating various physiological and pathological processes. Using advanced techniques like Pulsed Interleaved Excitation-Fluorescence Cross-Correlation Spectroscopy (PIE-FCCS), the study aims to uncover the structural and functional differences between these proteins and how they influence cell behavior. By understanding these interactions, researchers hope to gain insights into their roles in cancer and other diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by the signaling pathways regulated by EphA1 and EphA2.
Not a fit: Patients with conditions unrelated to the signaling pathways of EphA1 and EphA2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the mechanisms of cancer cell growth and migration.
How similar studies have performed: Previous research has shown promising results in understanding similar protein interactions, suggesting potential for success in this area.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, BINGCHENG — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: WANG, BINGCHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer cell line