Investigating how two proteins interact to regulate cell functions
Official title: EphA1 homotypic and EphA1-EphA2 heterotypic interactions in cell regulation
Funded at Case Western Reserve University · NIH-11049238 · Data updated 2026-11-12
This study is looking at how two important proteins, EphA1 and EphA2, work together and affect cell behavior, which could help us understand their roles in cancer and other diseases, and possibly lead to new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 5, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $693,134 |
| NIH project number | 1R01CA297778-01A1 |
| Project ID | NIH-11049238 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may be influenced by the signaling pathways regulated by EphA1 and EphA2.
✕Less likely to help
Patients with conditions unrelated to the signaling pathways of EphA1 and EphA2 may not benefit from this research.
What this research studies
This research focuses on the interactions between two proteins, EphA1 and EphA2, which play crucial roles in regulating various physiological and pathological processes. Using advanced techniques like Pulsed Interleaved Excitation-Fluorescence Cross-Correlation Spectroscopy (PIE-FCCS), the study aims to uncover the structural and functional differences between these proteins and how they influence cell behavior. By understanding these interactions, researchers hope to gain insights into their roles in cancer and other diseases, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the mechanisms of cancer cell growth and migration.
How similar studies have gone: Previous research has shown promising results in understanding similar protein interactions, suggesting potential for success in this area.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Wang, Bingcheng — Case Western Reserve University
- Study coordinator: Wang, Bingcheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.