Investigating how two proteins interact to protect against Alzheimer's disease.
Official title: SSH1-Nrf2 nexus in tipping the balance between degeneration and protection in tauopathies.
Funded at Case Western Reserve University · NIH-10987010 · Data updated 2026-11-12
This study is looking at how two proteins, SSH1 and Nrf2, work together in the brain during Alzheimer's disease to see if they can help protect against damage or make things worse, which could lead to new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $460,922 |
| NIH project number | 5R01AG080924-03 |
| Project ID | NIH-10987010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related tauopathies.
✕Less likely to help
Patients with non-tauopathies or those without cognitive impairment may not benefit from this research.
What this research studies
This research explores the relationship between two proteins, SSH1 and Nrf2, which play a crucial role in the brain's response to oxidative stress, particularly in the context of Alzheimer's disease. The study aims to understand how these proteins can either promote degeneration or provide protection against the harmful effects of tau protein accumulation and neuroinflammation. By using various models, including animal and cellular systems, the researchers will investigate the mechanisms that govern this interaction and its implications for Alzheimer's pathology.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the brain's protective responses against Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting oxidative stress pathways in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Kang, David E — Case Western Reserve University
- Study coordinator: Kang, David E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.