Investigating how two proteins interact to protect against Alzheimer's disease.
SSH1-Nrf2 nexus in tipping the balance between degeneration and protection in tauopathies.
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10987010
This study is looking at how two proteins, SSH1 and Nrf2, work together in the brain during Alzheimer's disease to see if they can help protect against damage or make things worse, which could lead to new ways to help people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10987010 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between two proteins, SSH1 and Nrf2, which play a crucial role in the brain's response to oxidative stress, particularly in the context of Alzheimer's disease. The study aims to understand how these proteins can either promote degeneration or provide protection against the harmful effects of tau protein accumulation and neuroinflammation. By using various models, including animal and cellular systems, the researchers will investigate the mechanisms that govern this interaction and its implications for Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related tauopathies.
Not a fit: Patients with non-tauopathies or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the brain's protective responses against Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting oxidative stress pathways in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANG, DAVID E — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: KANG, DAVID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease brain, Alzheimer's disease pathology