Investigating how two genes interact to influence Alzheimer's disease risk.
Official title: Resolving the genetic interaction between DAB1 and APOE4 in Alzheimer's.
Funded at Upstate Medical University · NIH-10782478 · Data updated 2026-11-12
This study is looking at how two specific genes, APOE4 and DAB1, work together and affect the risk and timing of Alzheimer's disease, with the hope that what we learn can help find new ways to prevent or treat the condition for people at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $203,750 |
| NIH project number | 5R21AG080800-02 |
| Project ID | NIH-10782478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who carry the APOE4 variant and are at risk for developing Alzheimer's disease.
✕Less likely to help
Patients who do not carry the APOE4 variant or have a different form of dementia may not benefit from this research.
What this research studies
This research explores the genetic relationship between the APOE4 gene, a major risk factor for Alzheimer's disease, and the DAB1 gene, which may influence the likelihood and age of onset of the disease. By studying these genes in mouse models and cell cultures, the researchers aim to understand how they work together to affect brain function and contribute to Alzheimer's. Patients may benefit from insights gained about genetic factors that could lead to new prevention or treatment strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new approaches to prevent or treat Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding genetic interactions related to Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Howell, Brian W. — Upstate Medical University
- Study coordinator: Howell, Brian W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.