Investigating how tumors use energy differently than healthy tissues
Measuring and manipulating metabolic fluxes in the tumor microenvironment
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10932994
This study is looking at how cancer cells use energy differently than normal cells and how changing your diet, especially with a high-fat ketogenic diet, might help improve cancer treatment when combined with chemotherapy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10932994 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the unique metabolic processes of tumors compared to normal tissues. By using advanced techniques to measure metabolic fluxes in living organisms, the study aims to uncover how cancer cells and other cells in the tumor microenvironment utilize energy. The researchers will explore the effects of dietary changes on tumor metabolism and growth, particularly looking at how a high-fat ketogenic diet can influence tumor behavior when combined with chemotherapy. This approach could lead to new strategies for targeting tumor metabolism in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with breast cancer or other tumors who are undergoing treatment and are interested in innovative metabolic therapies.
Not a fit: Patients with non-cancerous conditions or those who do not have tumors may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that specifically target tumor metabolism while minimizing harm to healthy tissues.
How similar studies have performed: Previous research has shown promising results in manipulating tumor metabolism, indicating that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARTMAN, CAROLINE — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BARTMAN, CAROLINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer Model, Breast Cancer cell line, Burn injury