Investigating how tumor variability affects treatment response in pediatric brain cancer.
Official title: Research Project 1: Diffuse Midline Glioma
Funded at Dana-Farber Cancer Inst · NIH-10931435 · Data updated 2026-11-12
This study is looking at how some brain tumors in kids, called diffuse midline gliomas, change after radiation treatment, to find out why they sometimes stop responding to therapy, with the hope of discovering better ways to help kids fight this cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $263,663 |
| NIH project number | 5U54CA274516-02 |
| Project ID | NIH-10931435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with diffuse midline glioma who are undergoing or have undergone radiation therapy.
✕Less likely to help
Patients with other types of brain tumors or those who are not receiving radiation therapy may not benefit from this research.
What this research studies
This research focuses on diffuse midline glioma (DMG), a type of brain cancer in children that initially responds to radiation therapy but ultimately progresses. The project aims to understand the variability within tumors that may contribute to treatment resistance and relapse. By utilizing advanced techniques like single cell genomics, researchers will analyze the genetic and biological differences within tumor cells before and after radiation therapy. This approach seeks to uncover the underlying mechanisms that lead to treatment failure, potentially guiding more effective therapies in the future.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for pediatric brain cancer, enhancing survival rates and quality of life for affected children.
How similar studies have gone: Other research has shown promise in understanding tumor heterogeneity and its impact on treatment outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Haas-Kogan, Daphne a. — Dana-Farber Cancer Inst
- Study coordinator: Haas-Kogan, Daphne a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.