Investigating how tumor environments affect gene regulation in cancer cells
Perturbation based single cell investigation of tumor micro-environment
This study is looking at how certain proteins that control gene activity work in both healthy and cancerous cells, using advanced techniques to better understand how they affect tumor growth and stem cell behavior, and it’s designed for patients interested in the genetic factors behind their cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10913319 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between transcription factors and gene expression in cancer. By using advanced single-cell techniques, the study aims to dissect how these factors regulate gene activity in both normal and tumor tissues. Patients' genetic information will be utilized to create models that help explore these regulatory networks, particularly in relation to stem cell behavior and tumor development. The research employs innovative methods like ATAC-seq and RNA-seq to analyze gene regulation at a cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with various types of cancer, particularly those with mutations in transcription factors.
Not a fit: Patients with non-cancerous conditions or those not exhibiting mutations in relevant transcription factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and potential therapeutic targets for treatment.
How similar studies have performed: Other research has shown promising results using similar single-cell approaches to investigate gene regulation in cancer, indicating a strong potential for success.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Chi — Dana-Farber Cancer Inst
- Study coordinator: Zhang, Chi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.