Investigating how tumor cells change to spread and resist treatment
To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models
This study is looking at how cancer cells change and spread in the body, which can make them harder to treat, and it's for anyone interested in understanding how we might improve cancer treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10866436 on NIH RePORTER |
What this research studies
This research focuses on understanding the process of epithelial to mesenchymal transition (EMT) in tumor cells, which is believed to play a critical role in how cancers spread and resist chemotherapy. By using advanced mouse models, researchers aim to trace the EMT process in real-time and identify how these changes contribute to tumor metastasis and treatment resistance. The study will explore different genetic factors involved in EMT to provide insights into the mechanisms that allow tumors to evade therapies. This could lead to new strategies for improving cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those experiencing metastasis or resistance to chemotherapy.
Not a fit: Patients with non-breast cancer types or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by targeting the mechanisms that allow tumors to spread and resist chemotherapy.
How similar studies have performed: Previous research has shown promising results in understanding EMT in cancer, suggesting that this approach could yield valuable insights, although the specific lineage tracing models used in this study may be novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Gao, Dingcheng — Weill Medical Coll of Cornell Univ
- Study coordinator: Gao, Dingcheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.