Investigating how tumor cells affect immune cells in lung cancer
Official title: CSF1 Receptor-Mediated Tumor Microenvironment in Lung Cancer
Funded at Jesse Brown VA Medical Center · NIH-11075194 · Data updated 2026-11-12
This study is looking at how certain immune cells in lung cancer are affected by a substance made by tumors, with the goal of finding new ways to improve cancer treatments that help your immune system fight the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX004981-06 |
| Project ID | NIH-11075194 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with lung cancer who may be eligible for immunotherapy.
✕Less likely to help
Patients with non-cancerous conditions or those not diagnosed with lung cancer may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific immune cells, particularly macrophages and dendritic cells, in the tumor microenvironment of lung cancer. The team of immunologists and oncologists aims to explore how tumor-produced Colony Stimulating Factor 1 (CSF1) alters these immune cells to promote cancer progression. By examining the mechanisms of CSF1 and its effects on myeloid cells, the research seeks to identify new therapeutic strategies that could enhance cancer immunotherapy. Patients may benefit from insights that could lead to more effective treatments targeting the tumor microenvironment.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that improve treatment outcomes for lung cancer patients.
How similar studies have gone: Other research has shown promise in targeting tumor microenvironments for cancer treatment, suggesting that this approach could yield significant insights.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Park, Gye Young — Jesse Brown VA Medical Center
- Study coordinator: Park, Gye Young
Related research
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Integrative Analysis of Lung Cancer Risk and Its Causes
A large, multi-part study at the University of New Mexico is exploring why lung cancer happens and how to better prevent and detect it.
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Integrative Analysis of Lung Cancer Risk and Causes
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Digital health strategies to expand lung cancer screening in safety-net clinics
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Proteomics-guided matching of lung cancer tumors to preclinical models
This grant aims to improve how we match a patient’s lung cancer tumor to the right preclinical models using protein data.
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Optimizing lung cancer care with smart tools for prevention, early detection, treatment, and survivorship
A U01 grant using AI and biomarkers to improve lung cancer prevention, screening, treatment, and survivorship care for people at risk or living with lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.