Investigating how tumor cell clusters and individual cells spread in ovarian cancer
The role of multi-cellular aggregates vs. individual tumor cells in metastasis of high-grade serous ovarian cancer
This study is looking at how high-grade serous ovarian cancer spreads in the body, especially through the abdominal fluid, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11003361 on NIH RePORTER |
What this research studies
This research focuses on understanding how high-grade serous ovarian cancer (HGSOC) spreads within the body, particularly through a process called transcoelomic spread. Researchers will examine both single tumor cells and clusters of cells found in the abdominal fluid of patients to see how they contribute to metastasis. By using advanced engineering techniques and biological assays, the study aims to uncover the mechanisms behind this spread and identify potential targets for future treatments. The collaborative team includes experts from various fields to ensure a comprehensive approach to the problem.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with high-grade serous ovarian cancer who are experiencing metastatic disease.
Not a fit: Patients with early-stage ovarian cancer or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or controlling the spread of ovarian cancer, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding cancer metastasis through similar approaches, but this specific investigation into HGSOC is relatively novel.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kreeger, Pamela K — University of Wisconsin-Madison
- Study coordinator: Kreeger, Pamela K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.