Investigating how Tsc1 affects neuron activity and brain function related to autism
Official title: Tsc1 Regulation of Purkinje Neuron Firing and Cerebellar Function
Funded at Miami University Oxford · NIH-10360002 · Data updated 2026-11-12
This study is looking at how a gene related to autism affects certain brain cells in mice, hoping to learn more about how these changes might relate to behaviors seen in autism, which could eventually help find new ways to support people with the condition.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Miami University Oxford NIH-funded |
| Lab location | 1 site (Oxford, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $361,250 |
| NIH project number | 1R15NS125560-01 |
| Project ID | NIH-10360002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with a genetic link to tuberous sclerosis.
✕Less likely to help
Patients without autism spectrum disorder or those not linked to tuberous sclerosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of Tsc1, a gene linked to autism spectrum disorder (ASD), in the functioning of Purkinje neurons in the cerebellum. By using a mouse model with specific genetic modifications, the study aims to explore how changes in these neurons' firing rates may contribute to behaviors associated with ASD. The researchers will analyze the molecular and biophysical alterations that lead to these changes in neuron activity, providing insights into the underlying mechanisms of ASD. This work could help identify potential therapeutic targets for improving symptoms in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or managing autism spectrum disorder symptoms.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and neuronal mechanisms underlying autism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Miami University Oxford
Oxford, United States Active
Researchers
- Principal investigator: Ransdell, Joseph L. — Miami University Oxford
- Study coordinator: Ransdell, Joseph L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.