Investigating how TSC proteins affect lymphatic vessels in Tuberous Sclerosis Complex
TSC Proteins in the Lymphatic Vasculature
This study is looking at how changes in certain genes related to Tuberous Sclerosis Complex (TSC) might affect the lymphatic system and cause problems like fluid buildup in the chest, with the goal of finding new ways to improve treatments for people with TSC.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10841591 on NIH RePORTER |
What this research studies
This research focuses on Tuberous Sclerosis Complex (TSC), a chronic condition caused by mutations in the TSC1 or TSC2 genes, leading to the formation of tumors in various organs. The study aims to explore the role of lymphatic vessels in TSC, particularly how mutations may affect their function and contribute to complications like chylothorax, a serious condition involving fluid accumulation in the chest. By examining the lymphatic vasculature in detail, researchers hope to identify new molecular targets and signaling pathways that could lead to better treatments for TSC. The approach includes using animal models to observe the effects of TSC gene deletion on lymphatic function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Tuberous Sclerosis Complex, particularly those experiencing complications like chylothorax.
Not a fit: Patients without Tuberous Sclerosis Complex or those not experiencing lymphatic-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing Tuberous Sclerosis Complex and its associated complications.
How similar studies have performed: While the involvement of lymphatic vessels in TSC is a relatively novel area of investigation, preliminary data suggest that similar approaches have shown promise in understanding other conditions.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yang, Ying — University of South Florida
- Study coordinator: Yang, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.