Investigating how tryptophan metabolism affects fibroid development
Tryptophan metabolism and its role in fibroid pathogenesis
This study is looking at how the way your body processes a substance called tryptophan might be linked to the growth of fibroids, especially in African American women, to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project ID | NIH-10888250 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of tryptophan metabolism in the development of fibroids, particularly examining the overexpression of specific enzymes like Tryptophan 2,3 dioxygenase (TDO2) and Indoleamine 2,3-dioxygenase (IDO1) in fibroid tissues. The study utilizes advanced techniques such as qRT-PCR and Western blot analysis to confirm these findings. It also explores how these metabolic changes are influenced by race, with a notable emphasis on the higher expression levels found in African American patients. By investigating the underlying mechanisms, the research aims to identify potential therapeutic targets for fibroid treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with fibroids, particularly those who are African American, as they may experience different metabolic profiles related to fibroid pathogenesis.
Not a fit: Patients without fibroids or those who do not belong to the populations being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from fibroids by targeting metabolic pathways involved in their development.
How similar studies have performed: While the specific focus on tryptophan metabolism in fibroids may be novel, previous research has shown success in targeting metabolic pathways for other conditions, suggesting potential for impactful findings.
Where this research is happening
Torrance, United States
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, United States (Active)
Researchers
- Principal investigator: Khorram, Omid a. — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Khorram, Omid a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.