Investigating how tryptophan derivatives affect EHEC bacteria
Tryptophan derivatives in EHEC pathogenesis
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11012378
This study is looking at how certain compounds from tryptophan, like indole and serotonin, can help improve gut health and fight off harmful bacteria like E. coli, which could be helpful for people dealing with gut issues or infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11012378 on ClinicalTrials.gov |
What this research studies
This research explores the role of tryptophan derivatives, particularly indole and serotonin, in the interaction between gut bacteria and the intestinal barrier. It focuses on how these compounds can influence the behavior of enterohemorrhagic E. coli (EHEC) and its virulence. By using animal models, the study aims to understand the mechanisms by which these signaling molecules can enhance gut health and potentially reduce bacterial pathogenicity. Patients may benefit from insights gained about gut health and bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal issues or those at risk of EHEC infections.
Not a fit: Patients who do not have gastrointestinal conditions or are not at risk for EHEC infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by EHEC and improving gut health.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiota and signaling molecules in bacterial pathogenesis, suggesting potential for success in this area.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPERANDIO, VANESSA — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: SPERANDIO, VANESSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.