Investigating how tRNA modifications affect malaria drug resistance
tRNA modification reprogramming in artemisinin-resistant Plasmodium falciparum: An epigenetic driver of resistance?
['FUNDING_CAREER'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10899653
This study is looking at how changes in a part of the malaria parasite can help it resist a common treatment, with the goal of finding new ways to help patients who have malaria that doesn't respond to current drugs.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10899653 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain modifications to tRNA in the malaria-causing parasite, Plasmodium falciparum, contribute to its resistance against artemisinin, a key malaria treatment. The researchers will explore the molecular mechanisms behind this resistance, particularly how changes in tRNA can influence the parasite's ability to survive drug treatment. By studying these processes, the research aims to uncover potential new strategies for combating malaria in patients who are affected by drug-resistant strains.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with malaria, especially those who have been treated with artemisinin and are experiencing resistance.
Not a fit: Patients with malaria who are not infected with artemisinin-resistant strains may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for malaria patients, particularly those infected with drug-resistant strains.
How similar studies have performed: Other research has shown success in understanding drug resistance mechanisms in malaria, but this specific approach focusing on tRNA modifications is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMALL-SAUNDERS, JENNIFER L. — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SMALL-SAUNDERS, JENNIFER L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.