Investigating how tRNA-derived RNAs control cell responses to stress
tRNA-derived stress-induced RNAs and translational control
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10868575
This study is looking at how tiny pieces of RNA, called tRNA-derived fragments, help cells respond to stress, especially in conditions like ALS, to find new ways to improve cell survival and develop better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10868575 on ClinicalTrials.gov |
What this research studies
This research explores the role of tRNA-derived fragments (tRFs) in regulating cellular responses to stress, particularly in conditions like amyotrophic lateral sclerosis (ALS). The study focuses on how specific tRNA-derived stress-induced RNAs (tiRNAs) can influence translation processes in cells, potentially affecting cell survival and apoptosis. By utilizing advanced techniques, including CRISPR methodologies, the research aims to uncover novel mechanisms of translation regulation that could lead to new therapeutic strategies for stress-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those not experiencing cellular stress responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cell survival and function in patients with neurodegenerative diseases like ALS.
How similar studies have performed: Previous research has shown promising results in understanding the regulatory roles of tRNA-derived fragments, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IVANOV, PAVEL — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: IVANOV, PAVEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease