Investigating how tRNA-derived RNAs control cell functions under stress
tRNA-derived stress-induced RNAs and translational control
This study is looking at tiny pieces of RNA that help cells cope with stress, especially in conditions like ALS, to find new ways to support cell survival and possibly improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11097534 on NIH RePORTER |
What this research studies
This research explores the role of tRNA-derived fragments, specifically tRNA-derived stress-induced RNAs (tiRNAs), in regulating cell functions during stress conditions. By examining how these small RNAs influence translation initiation and cell survival, the study aims to uncover new mechanisms that cells use to adapt to various stressors. The research involves laboratory experiments that analyze the effects of tiRNAs on cellular processes, particularly in the context of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Patients may benefit from insights gained into how these mechanisms could be targeted for therapeutic purposes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or other degenerative neurologic disorders.
Not a fit: Patients with non-neurological conditions or those not experiencing cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by enhancing cell survival under stress.
How similar studies have performed: Other research has shown promising results in understanding the regulatory roles of tRNA-derived fragments, indicating that this area of study is gaining traction in molecular biology.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ivanov, Pavel — Brigham and Women's Hospital
- Study coordinator: Ivanov, Pavel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.