Investigating how trichloroethylene exposure affects Parkinson's disease development
Official title: The role of lysosomal impairment in trichloroethylene induced Parkinsonian neurodegeneration
Funded at University of Alabama at Birmingham · NIH-11199777 · Data updated 2026-11-12
This study is looking at how a chemical called trichloroethylene (TCE) might be linked to Parkinson's disease and aims to find out how it affects brain cells, which could help us discover new ways to prevent or treat the condition for people living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 25, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $122,700 |
| NIH project number | 3R01ES034846-02S1 |
| Project ID | NIH-11199777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have been exposed to trichloroethylene and are at risk for developing Parkinson's disease.
✕Less likely to help
Patients who have not been exposed to trichloroethylene or do not have a risk of developing Parkinson's disease may not benefit from this research.
What this research studies
This research focuses on understanding the connection between exposure to the chemical trichloroethylene (TCE) and the development of Parkinson's disease (PD). It examines how TCE impairs the autophagy-lysosomal pathway, leading to the accumulation of misfolded proteins and neurodegeneration. By studying both genetic and environmental factors, the research aims to uncover the mechanisms that contribute to PD, particularly in relation to lysosomal function. Patients may benefit from insights that could lead to new prevention or treatment strategies for Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Parkinson's disease linked to environmental exposures.
How similar studies have gone: Previous research has shown that environmental exposures can significantly impact the development of Parkinson's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: De Miranda, Briana — University of Alabama at Birmingham
- Study coordinator: De Miranda, Briana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.