Investigating how TREM2 proteins and their variants affect Alzheimer's disease
Mapping protein interactome of TREM2 and its variants to probe the etiology of Alzheimer's Disease
This study is looking at a protein called TREM2 to see how it interacts with other proteins in the brain and how certain genetic changes might raise the risk of Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10642677 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TREM2, a protein involved in the immune response in the brain, particularly in relation to Alzheimer's disease (AD). The study aims to map the interactions of TREM2 with other proteins to uncover how certain genetic variants increase the risk of developing AD. By using advanced techniques to analyze these protein interactions, researchers hope to identify new pathways and mechanisms that contribute to the disease. This could lead to a better understanding of how AD develops and potentially inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those who carry specific TREM2 genetic variants.
Not a fit: Patients with early-onset Alzheimer's disease or those without any genetic predisposition related to TREM2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and pave the way for targeted therapies.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic variants in Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Gao, Jie — Ohio State University
- Study coordinator: Gao, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.