Investigating how TREM-1 affects allergic airway inflammation in military personnel
Official title: The Role of TREM-1 in the Regulation of Allergic Airway Inflammation
Funded at Iowa City VA Medical Center · NIH-11051770 · Data updated 2026-11-12
This study is looking at how a specific immune protein called TREM-1 affects breathing problems, like asthma, in U.S. military personnel who have been exposed to allergens during their deployments, with the hope of finding better ways to prevent and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa City VA Medical Center NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX005989-02 |
| Project ID | NIH-11051770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel who have been deployed to Iraq or Afghanistan and are experiencing respiratory symptoms or have been diagnosed with asthma.
✕Less likely to help
Patients who have not been deployed to areas with known airborne allergens or who do not have respiratory symptoms may not benefit from this research.
What this research studies
This research focuses on understanding the role of TREM-1 in allergic airway inflammation, particularly among U.S. military personnel who have been deployed to areas with high levels of airborne allergens. The study aims to explore how exposure to environmental factors, such as particulate matter and diesel fuel, may trigger or worsen respiratory conditions like asthma. By examining the immune response, particularly the activation of T cells and neutrophils, the research seeks to identify mechanisms that contribute to allergic airway diseases. This could lead to better prevention and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of allergic airway diseases in military personnel and potentially other populations exposed to similar environmental triggers.
How similar studies have gone: Previous studies have shown that understanding immune responses to allergens can lead to significant advancements in treating allergic conditions, suggesting that this research could build on established findings.
Where this research is happening
-
Iowa City VA Medical Center
Iowa City, United States Active
Researchers
- Principal investigator: Klesney-Tait, Julia a — Iowa City VA Medical Center
- Study coordinator: Klesney-Tait, Julia a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.