Investigating how TREK-1 affects heart rhythm and arrhythmias
Role of TREK-1 in modulating cardiac excitability and arrhythmia
This study is looking at a specific channel in the heart called TREK-1 to see how it affects heart rhythms and could help find new ways to treat heart rhythm problems for people with heart conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10783003 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the TREK-1 channel in the heart, particularly how it influences cardiac excitability and the risk of arrhythmias. By studying this channel, researchers aim to identify new therapeutic approaches that can better manage heart rhythm disturbances. The methodology includes examining the channel's behavior in heart cells and exploring its potential as a target for new anti-arrhythmic drugs. This work is crucial for developing more effective and patient-friendly treatments for those suffering from cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular disease who experience arrhythmias or are at risk for developing them.
Not a fit: Patients without cardiovascular disease or those who do not experience arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and safer treatments for patients with heart rhythm disorders.
How similar studies have performed: Previous research has shown promise in targeting ion channels for arrhythmia treatment, but the specific focus on TREK-1 is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Hund, Thomas Jeffrey — Ohio State University
- Study coordinator: Hund, Thomas Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.