Investigating how traumatic brain injuries affect nerve cell health
Traumatic Axonopathy in the CNS as Wallerian degeneration
This study is looking at how certain injuries to the brain can harm nerve cells and aims to find ways to protect those cells and help improve movement after an injury, especially by focusing on a specific signal called SARM1.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11026382 on NIH RePORTER |
What this research studies
This research focuses on understanding how traumatic axonal injury (TAI) leads to nerve cell damage in the central nervous system. The team aims to identify specific molecular signals involved in this process, particularly the role of SARM1 signaling, which may contribute to the degeneration of axons. By exploring ways to block these signals, the researchers hope to protect axons and improve brain function after injury. The study involves both genetic and pharmacological approaches to assess the potential for preserving nerve cell integrity and restoring motor skills.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced traumatic brain injuries and exhibit signs of axonal damage.
Not a fit: Patients with complete axonal loss or those who do not have a history of traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect nerve cells and improve recovery outcomes for patients with traumatic brain injuries.
How similar studies have performed: Previous research has shown promise in targeting molecular pathways for neuroprotection, suggesting that this approach may yield significant advancements in treatment.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Koliatsos, Vassilis E — Johns Hopkins University
- Study coordinator: Koliatsos, Vassilis E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.