Investigating how transposon activity affects Alzheimer's and aging in the brain
Role of transposon dysregulation in Alzheimer and aging brains revealed by single-cell genomic and transcriptomic analysis
This study is looking at how certain genetic elements in the brain might affect inflammation and aging in people with Alzheimer's Disease, helping us understand more about how the disease works and how it changes our brains as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10865058 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of transposable elements (TEs) in the brains of individuals with Alzheimer's Disease (AD) and during the aging process. By using advanced genomic and transcriptomic analysis techniques, the study aims to identify how TEs contribute to inflammation and cell aging at the individual cell level. The researchers will explore the unique changes in different brain cell types and develop new computational tools to analyze these complex interactions. This work could provide insights into the mechanisms of neurodegeneration and aging-related brain diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or those experiencing age-related cognitive decline.
Not a fit: Patients with early-stage cognitive impairment not related to aging or Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's Disease and other age-related neurodegenerative conditions.
How similar studies have performed: Previous research has shown that understanding the role of transposable elements in neurodegeneration can lead to significant insights, suggesting this approach has potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Eunjung Alice — Boston Children's Hospital
- Study coordinator: Lee, Eunjung Alice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.