Investigating how tPA affects blood flow regulation in Alzheimer's disease
tPA and Cerebrovascular Regulation in a Model of ß-amyloid Pathology
This study is looking at how a protein called tPA helps control blood flow in the brain and how it gets affected by Alzheimer's disease, with the hope of finding new ways to improve brain function and memory for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11044995 on NIH RePORTER |
What this research studies
This research explores the role of tissue plasminogen activator (tPA) in regulating blood flow in the brain, particularly in the context of Alzheimer's disease and related dementias. It focuses on understanding how amyloid-beta, a key factor in Alzheimer's pathology, disrupts normal blood flow regulation by inhibiting tPA activity. By identifying the cellular sources of PAI-1, which inhibits tPA, the study aims to uncover new therapeutic strategies to improve brain function and cognitive abilities in affected individuals. Patients may benefit from insights that could lead to innovative treatments targeting neurovascular dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurodegenerative cognitive impairments or those without Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and daily living activities for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding neurovascular dysfunction in Alzheimer's, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Park, Laibaik — Weill Medical Coll of Cornell Univ
- Study coordinator: Park, Laibaik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.