Investigating how Toxoplasma parasites divide to find new drug targets
The Toxoplasma basal complex in cell division
This study is looking at how a parasite called Toxoplasma gondii divides, especially to help people with weakened immune systems, and it aims to find new ways to treat infections by discovering weaknesses in the parasite's process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston College NIH-funded |
| Lab location | 1 site (Chestnut Hill, United States) |
| Project ID | NIH-10765625 on NIH RePORTER |
What this research studies
This research focuses on Toxoplasma gondii, a parasite that can cause serious infections, particularly in individuals with weakened immune systems. The project aims to understand the unique way these parasites divide, which could lead to the identification of new drug targets. By studying the cellular structures involved in the division process, researchers hope to uncover vulnerabilities that can be exploited for new treatments. The methodology includes advanced techniques like proteomic analysis to dissect the components involved in cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems, such as those with HIV/AIDS or undergoing chemotherapy, who are at risk for Toxoplasma infections.
Not a fit: Patients who are not immunocompromised or those who do not have a history of Toxoplasma infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for infections caused by Toxoplasma gondii.
How similar studies have performed: Previous research has successfully identified drug targets in similar parasitic organisms, suggesting that this approach may yield valuable insights.
Where this research is happening
Chestnut Hill, United States
- Boston College — Chestnut Hill, United States (Active)
Researchers
- Principal investigator: Gubbels, Marc-Jan — Boston College
- Study coordinator: Gubbels, Marc-Jan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.