Investigating how topoisomerase 1 removes ribonucleotides from DNA.
Topoisomerase 1-catalyzed genomic ribonucleotide excision, its regulation, and its implication in transcription.
This study is looking at how a special enzyme helps fix mistakes in DNA that can happen when cells are copying themselves, which might lead to problems like cancer, especially breast cancer, and it hopes to find ways to improve our understanding of these issues for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10923999 on NIH RePORTER |
What this research studies
This research explores the role of topoisomerase 1 in removing ribonucleotides that are mistakenly incorporated into DNA during replication. It aims to understand the mechanisms behind this process, particularly how it can lead to deletions in the DNA sequence. By studying the specific conditions under which topoisomerase 1 operates, the research seeks to uncover the biological implications of these deletions, especially in relation to gene transcription. Patients may benefit from insights gained into how these processes affect cancer development, particularly in breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast cancer or those who carry mutations in the BRCA1 or BRCA2 genes.
Not a fit: Patients without a genetic predisposition to breast cancer or those not affected by related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors in breast cancer, potentially guiding more effective treatments.
How similar studies have performed: Other research has shown promising results in understanding the role of topoisomerases in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Sarrain, Edward James — Trustees of Indiana University
- Study coordinator: Sarrain, Edward James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.