Investigating how TOCA proteins affect cell behavior and shape
Official title: Role of TOCA proteins in glia: from cellular morphology to animal behavior
Funded at University of Miami School of Medicine · NIH-11063156 · Data updated 2026-11-12
This study is looking at how certain proteins help shape cell membranes, which is important for how cells move and work, and it aims to find out how this relates to diseases like cancer and brain disorders, so that we can develop better treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $171,278 |
| NIH project number | 5R21NS137641-02 |
| Project ID | NIH-11063156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancer or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to cell motility or membrane biology may not benefit from this research.
What this research studies
This research explores the role of TOCA proteins in changing the shape of cell membranes, which is crucial for cell movement and function. By using the model organism C. elegans, the researchers aim to understand how these proteins contribute to various diseases, including cancer and neurodegenerative disorders. The study will utilize advanced imaging techniques to analyze the structure and function of these proteins in living organisms, providing insights that could lead to new therapeutic strategies. Patients may benefit from a better understanding of how these proteins influence disease processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancer and other diseases linked to cell behavior.
How similar studies have gone: Other research has shown promise in understanding membrane proteins and their roles in disease, suggesting potential for success in this area.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Bianchi, Laura — University of Miami School of Medicine
- Study coordinator: Bianchi, Laura
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.