Investigating how tobacco-specific chemicals damage DNA in human oral cells
Carcinogenic tobacco-specific nitrosamines induction of apurinic/apyrimidinic sites in DNA of human oral cells
This study is looking at how harmful chemicals in tobacco can damage DNA in the cells of your mouth, and it’s for people who use cigarettes, smokeless tobacco, or e-cigarettes, to help understand the early signs of cancer.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan Technological University NIH-funded |
| Lab location | 1 site (Houghton, United States) |
| Project ID | NIH-10856299 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain harmful chemicals found in tobacco products, specifically tobacco-specific nitrosamines, can cause damage to DNA in human oral cells. The researchers will develop a sensitive method to measure specific types of DNA damage known as apurinic/apyrimidinic (AP) sites, which may indicate the early stages of cancer development. By analyzing DNA from oral cells of individuals who use cigarettes, smokeless tobacco, or e-cigarettes, the study aims to establish a link between tobacco use and DNA damage that could lead to cancer. This work could provide valuable insights into the carcinogenic effects of tobacco and help identify biomarkers for early detection of oral cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who use tobacco products, including cigarettes, smokeless tobacco, or e-cigarettes.
Not a fit: Patients who do not use tobacco products or have no history of tobacco exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and early detection of oral cancers caused by tobacco use.
How similar studies have performed: Previous research has shown that analyzing DNA damage in oral cells can provide important insights into cancer risk, making this approach promising and relevant.
Where this research is happening
Houghton, United States
- Michigan Technological University — Houghton, United States (Active)
Researchers
- Principal investigator: Guo, Jiehong — Michigan Technological University
- Study coordinator: Guo, Jiehong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.