Investigating how to stop ovarian endometriomas from growing and causing cancer
Targeting cellular senescence to inhibit the development and progression of ovarian endometriomas
This study is looking at painful ovarian endometriomas in mice to understand what causes them and how they might lead to more serious health problems, with the hope of finding better treatments than what we have now.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10889117 on NIH RePORTER |
What this research studies
This research focuses on ovarian endometriomas, which are painful lesions that can lead to serious health issues, including cancer. The study uses a mouse model that mimics human endometriomas to explore the underlying causes and mechanisms of these lesions. By examining the role of cellular senescence, the research aims to identify potential therapeutic targets that could prevent the progression of endometriomas. This approach may lead to new treatments that are more effective than current hormonal therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women over 21 years old who are experiencing ovarian endometriomas or related symptoms.
Not a fit: Patients who do not have ovarian endometriomas or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage or prevent ovarian endometriomas and their associated risks.
How similar studies have performed: While the specific approach of targeting cellular senescence in endometriomas is novel, similar strategies have shown promise in other areas of cancer research.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Hawkins, Shannon Michelle — Indiana University Indianapolis
- Study coordinator: Hawkins, Shannon Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.