Investigating how to stabilize collagen IV for better tissue health
Official title: Chemical Biology Approaches to Studying Collagen IV Stability
Funded at University of California, San Francisco · NIH-10723042 · Data updated 2026-11-12
This study is looking at how to make a key protein called collagen IV more stable, which could help improve treatments for conditions like Osteogenesis Imperfecta and Ehlers-Danlos syndrome that affect your body's tissues and can lead to serious health problems.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $435,659 |
| NIH project number | 1R21EY035366-01 |
| Project ID | NIH-10723042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with collagen-associated disorders like Osteogenesis Imperfecta or Ehlers-Danlos syndrome.
✕Less likely to help
Patients without collagen-related disorders or those not affected by genetic conditions related to collagen IV may not benefit from this research.
What this research studies
This research focuses on understanding the stability of collagen IV, a crucial protein that helps maintain the structure of various tissues in the body. By exploring the folding and assembly processes of collagen IV, the researchers aim to identify ways to enhance its stability through genetic or chemical methods. This could potentially lead to new treatments for genetic disorders that affect collagen, such as Osteogenesis Imperfecta and Ehlers-Danlos syndrome, which can cause significant health issues including vision loss. Patients may benefit from advancements in therapies that target these collagen-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with collagen-related disorders, enhancing their quality of life.
How similar studies have gone: Previous research has shown promise in stabilizing collagen through various approaches, indicating that this area of study has potential for significant advancements.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Gestwicki, Jason E — University of California, San Francisco
- Study coordinator: Gestwicki, Jason E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.