Investigating how to safely reduce opioid use in patients with chronic pain and substance use disorder.
Official title: Weighting Longitudinal Data to Access Opioid Analgesia Tapering Outcomes among Patients with Co-occurring Chronic Pain and Substance Use Disorder
Funded at Loyola University Chicago · NIH-10590322 · Data updated 2026-11-12
This study is looking at how reducing opioid use can help people with chronic pain who also struggle with substance use issues, and it aims to find better ways to manage their pain without relying on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2025 |
| Funding year | 2022 |
| Award (this year) | $2,093,521 |
| NIH project number | 1R01DA057658-01 |
| Project ID | NIH-10590322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain who also have a history of substance use disorder.
✕Less likely to help
Patients who do not have chronic pain or substance use disorder may not benefit from this research.
What this research studies
This research focuses on understanding the outcomes of tapering opioid analgesics in patients who have both chronic pain and substance use disorder. It aims to analyze a large database of electronic health records to identify effective non-pharmacologic treatments and transitions to medications for opioid use disorder. By weighting the data from over 100 million patients, the study seeks to uncover trends and outcomes that can inform better pain management strategies for this vulnerable population. The approach emphasizes a multidisciplinary method to improve patient care and reduce reliance on opioids.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies that reduce opioid dependence and enhance the quality of life for patients with chronic pain and substance use disorder.
How similar studies have gone: Previous research has shown promising results in using non-pharmacologic approaches for pain management, indicating that this study builds on established findings while addressing a novel population.
Where this research is happening
-
Loyola University Chicago
Maywood, United States Active
Researchers
- Principal investigator: Qeadan, Fares — Loyola University Chicago
- Study coordinator: Qeadan, Fares
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.