Investigating how to reverse bone-like changes in blood vessels caused by diabetes
Switch of Osteogenesis in Vascular Calcification
This study is looking at how to help blood vessel cells in people with diabetes go back to normal instead of turning into bone-like cells, which can cause serious health problems, with the hope of finding new ways to improve heart and blood vessel health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10880261 on NIH RePORTER |
What this research studies
This research focuses on understanding vascular calcification, a common complication in diabetes that leads to serious health issues. The study aims to explore whether it is possible to revert the transformation of blood vessel cells into bone-like cells, which contributes to vascular calcification. By utilizing advanced techniques like single-cell RNA sequencing, the researchers will identify methods to encourage these cells to return to their original function. This could potentially lead to new treatments that improve vascular health in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing complications related to vascular calcification.
Not a fit: Patients without diabetes or those who do not have vascular calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that reduce vascular calcification and improve overall health outcomes for patients with diabetes.
How similar studies have performed: Previous studies have shown promising results in similar approaches, indicating potential for success in this novel investigation.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yao, Yucheng — University of California Los Angeles
- Study coordinator: Yao, Yucheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.