Investigating how to reprogram brain neurons for better function after injury or disease
Molecular Determinants for In vivo Functional Reprogramming of Cortical Output Neurons and Circuits
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-10884193
This study is looking at ways to help the brain heal itself after injuries or diseases like ALS by figuring out how to turn certain brain cells back into working neurons, which could lead to new treatments for recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10884193 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how to restore damaged brain circuitry caused by conditions like acquired brain injury and amyotrophic lateral sclerosis (ALS). The team aims to explore the mechanisms that prevent mature neurons from being reprogrammed into functional neurons that can replace those lost due to injury or disease. By studying specific types of neurons in the brain, they hope to identify barriers to reprogramming and develop strategies to overcome these challenges. This could lead to innovative treatments that enhance brain repair and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with acquired brain injuries or neurodegenerative diseases like ALS.
Not a fit: Patients with stable neurological conditions that do not involve neuron loss or damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore brain function and improve quality of life for patients with neurological conditions.
How similar studies have performed: While the approach of reprogramming neurons is promising, it is still largely experimental and has not yet been widely tested in human subjects.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALAZO, MARIA J — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: GALAZO, MARIA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Amyotrophic Lateral Sclerosis Motor Neuron Disease