Investigating how to repair white matter damage in vascular cognitive impairment and dementia
White Matter Injury and Repair in Vascular Cognitive Impairment and Dementia
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10630775
This study is looking at how a protein called adiponectin might help improve brain health and thinking skills in people with vascular cognitive impairment and dementia by supporting the repair of important brain cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10630775 on ClinicalTrials.gov |
What this research studies
This research focuses on vascular cognitive impairment and dementia (VCID), which is a common type of dementia characterized by damage to the brain's white matter. The study aims to understand how to enhance the repair of white matter by protecting and regenerating oligodendrocytes, the cells responsible for producing myelin. Researchers will explore the role of adiponectin, a protein found in the blood, in promoting white matter integrity and improving cognitive function in models of VCID. By examining the effects of adiponectin on white matter health, the research seeks to identify potential therapeutic strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline associated with vascular cognitive impairment or dementia.
Not a fit: Patients with cognitive impairment not related to vascular issues or those with other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for patients with vascular cognitive impairment and dementia.
How similar studies have performed: Previous research has shown promising results in enhancing cognitive function through similar approaches, indicating potential for success in this area.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, XIAOMING — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: HU, XIAOMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome