Investigating how to regenerate balance-related hair cells in the inner ear
Mouse and human vestibular regeneration and function
This study is looking at how to help people with balance problems by trying to grow new hair cells in the inner ear, using a special gene called ATOH1, and it’s for anyone who struggles with vestibular disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10982512 on NIH RePORTER |
What this research studies
This research focuses on understanding how to regenerate sensory hair cells in the vestibular system, which are crucial for maintaining balance. The study explores the effects of transient overexpression of a specific gene, ATOH1, on hair cell regeneration and maturation in both mouse models and human tissues. By using advanced techniques like single-cell RNA sequencing, researchers aim to identify the genetic characteristics of these regenerated cells and assess their functionality through various tests. The ultimate goal is to develop strategies that could restore balance function in individuals suffering from vestibular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing balance dysfunction due to vestibular hair cell degeneration.
Not a fit: Patients with balance issues not related to hair cell degeneration or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for balance disorders, reducing symptoms like dizziness and vertigo in affected patients.
How similar studies have performed: Previous studies have shown promise in enhancing hair cell regeneration through genetic manipulation, indicating a potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Cheng, Alan Gi-Lun — Stanford University
- Study coordinator: Cheng, Alan Gi-Lun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.